PRDM4

Across TCGA patient cohorts, PRDM4 mutation is significantly associated with the RNA expression of many other genes, with 2,947 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRDM4-associated genes across cancer lineages are OXNAD1, CHCHD4, and SMIM4. Each is linked with PRDM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRDM4-to-partner and partner-to-PRDM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OXNAD1 grouped by PRDM4-low versus PRDM4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM4→partner) and Y-score (partner→PRDM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OXNAD1 →	+0.252	+1.968	.006	<.001	3	2
UCEC	CHCHD4 →	+0.368	+3.140	<.001	<.001	3	2
UCEC	SMIM4 →	+0.585	+2.949	<.001	<.001	3	2
UCEC	SHMT1 →	+0.543	+2.577	<.001	<.001	3	2
UCEC	PIR →	+0.676	+2.285	.002	.005	3	2
READ	RNY4P14 →	+0.629	+5.421	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,947 associations by consensus.

OXNAD1 by PRDM4 expression — UCEC

Explore this box plot interactively →