PRDM16

Across TCGA patient cohorts, PRDM16 protein abundance is significantly associated with the RNA expression of many other genes, with 6,511 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PRDM16-associated genes across cancer lineages are DCN, GALNT15, and FBN1. Each is linked with PRDM16 in more than 4 cancer types. Because this analysis shows association rather than direction, both PRDM16-to-partner and partner-to-PRDM16 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRDM16 versus DCN in BRCA, with a Pearson correlation of 0.68.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM16→partner) and Y-score (partner→PRDM16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DCN →	+1.721	+0.688	<.001	<.001	3	5
BRCA	GALNT15 →	+1.288	+0.689	<.001	<.001	3	5
BRCA	FBN1 →	+1.602	+0.724	<.001	<.001	3	5
BRCA	SIGLEC17P →	+0.573	+0.655	.002	<.001	3	5
BRCA	TPSAB1 →	+1.722	+0.818	<.001	<.001	3	5
OV	SRPX →	+1.367	+0.768	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,511 associations by consensus.

PRDM16 vs DCN — BRCA

Explore this scatter interactively →