PRDM16

Across TCGA pan-cancer cohorts, PRDM16 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PRDM16’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PRDM16 RNA is repressed in tumor relative to normal tissue. In most cancer types PRDM16 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and THCA are the cancer types where PRDM16 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRDM16 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−3.017	<.001	12	view →
KIRP	Female	All	−3.290	<.001	11	view →
THCA	Male	III,IV	−2.440	<.001	11	view →
LUAD	Male	III,IV	−1.956	<.001	9	view →
LUSC	Female	II,III,IV	−2.274	<.001	8	view →
UCEC	All	All	−1.097	<.001	6	view →
BRCA	All	III,IV	−0.666	<.001	6	view →
HNSC	All	II,III,IV	+0.335	.003	6	view →
LIHC	All	All	+0.305	.001	6	view →
BLCA	All	All	−0.525	.005	4	view →
CHOL	All	All	+1.565	<.001	3	view →
READ	All	All	−0.812	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PRDM16–KIRC

Open the KIRC breakdown →