PRDM16

Across TCGA patient cohorts, PRDM16 mutation is significantly associated with the total protein of many other genes, with 79 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRDM16-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and eIF4E. Each is linked with PRDM16 in more than 3 cancer types. Because this analysis shows association rather than direction, both PRDM16-to-partner and partner-to-PRDM16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PRDM16-low versus PRDM16-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM16→partner) and Y-score (partner→PRDM16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.611	+3.824	<.001	<.001	3	4
STAD	4E-BP1 →	+0.361	+2.115	.002	.017	3	4
COAD	eIF4E →	+0.238	+3.472	<.001	.002	3	3
COAD	TSC1 →	-0.468	-2.807	<.001	.002	3	3
STAD	Cyclin-B1 →	+0.527	+2.807	.003	.003	2	4
COAD	eEF2 →	+0.354	+1.915	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

Caspase-7-cleavedD198 by PRDM16 expression — COAD

Explore this box plot interactively →