PRDM16

Across TCGA cell cohorts, PRDM16 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,352 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRDM16-associated GO terms across cancer lineages are Beige fat cell differentiation, Regulation of granulocyte differentiation, and Cell division. Each is linked with PRDM16 in more than 17 cancer types. Because this analysis shows association rather than direction, both PRDM16-to-partner and partner-to-PRDM16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Beige fat cell differentiation grouped by PRDM16-low versus PRDM16-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM16→partner) and Y-score (partner→PRDM16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Beige fat cell differentiation →	-0.391	-1.138	<.001	<.001	3	18
OESOPHAGUS	Regulation of granulocyte differentiation →	-0.150	-0.781	.001	.001	3	9
LUNG_NSCLC_LUSC	Cell division →	+0.087	+1.058	.001	<.001	3	7
LARGE_INTESTINE	Regulation of DNA repair →	+0.046	+0.847	.001	.003	3	7
LUNG_NSCLC_LUSC	Primary alcohol biosynthetic process →	-0.233	-0.908	.007	.007	2	7
OESOPHAGUS	Camera-type eye development →	-0.048	-1.229	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,352 associations by consensus.

Beige fat cell differentiation by PRDM16 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →