PRDM16

Across TCGA cell cohorts, PRDM16 mutation is significantly associated with the RNA expression of many other genes, with 322 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRDM16-associated genes across cancer lineages are H4C7, LRRTM3, and OR10K2. Each is linked with PRDM16 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRDM16-to-partner and partner-to-PRDM16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H4C7 grouped by PRDM16-low versus PRDM16-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM16→partner) and Y-score (partner→PRDM16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	H4C7 →	+0.276	+4.906	<.001	.006	3	2
BLOOD_Leukemia	LRRTM3 →	+0.002	+2.664	<.001	.009	3	2
BREAST	OR10K2 →	+0.031	+3.781	<.001	.009	3	2
LARGE_INTESTINE	NME3 →	+1.012	+2.158	.001	.004	3	2
LARGE_INTESTINE	TXNL4A →	+0.657	+2.850	<.001	<.001	3	2
LARGE_INTESTINE	SENP3 →	+0.443	+3.237	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 322 associations by consensus.

H4C7 by PRDM16 expression — OESOPHAGUS

Explore this box plot interactively →