PRDM16-DT

Across TCGA patient cohorts, PRDM16-DT mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRDM16-DT-associated genes across cancer lineages are MIR4510, RNU6-90P, and RN7SL680P. Each is linked with PRDM16-DT in more than 1 cancer types. Because this analysis shows association rather than direction, both PRDM16-DT-to-partner and partner-to-PRDM16-DT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4510 grouped by PRDM16-DT-low versus PRDM16-DT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM16-DT→partner) and Y-score (partner→PRDM16-DT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4510 →	+0.251	+4.132	<.001	.009	3	2
UCEC	RNU6-90P →	+0.663	+3.249	.002	.005	3	1
UCEC	RN7SL680P →	+0.209	+3.718	<.001	.004	3	1
UCEC	MIR7976 →	+0.675	+3.868	<.001	.001	3	1
UCEC	MIR4672 →	+0.806	+3.947	<.001	<.001	3	1
UCEC	RN7SL376P →	+0.377	+3.400	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

MIR4510 by PRDM16-DT expression — UCEC

Explore this box plot interactively →