PRDM14

Across TCGA patient cohorts, PRDM14 mutation is significantly associated with the RNA expression of many other genes, with 3,650 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRDM14-associated genes across cancer lineages are CKS2, RNA5-8SN2, and HAUS1. Each is linked with PRDM14 in more than 3 cancer types. Because this analysis shows association rather than direction, both PRDM14-to-partner and partner-to-PRDM14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CKS2 grouped by PRDM14-low versus PRDM14-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM14→partner) and Y-score (partner→PRDM14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	CKS2 →	+0.740	+3.330	.002	.005	3	4
READ	RNA5-8SN2 →	+0.190	+5.681	<.001	.001	3	3
COAD	HAUS1 →	+0.651	+3.223	.003	.009	3	3
UCEC	PBK →	+1.024	+2.595	<.001	<.001	3	3
SKCM	KMT5A →	+0.372	+2.453	.005	.001	3	3
UCEC	SAPCD2 →	+0.598	+1.906	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,650 associations by consensus.

CKS2 by PRDM14 expression — LUSC

Explore this box plot interactively →