PRDM14

Across TCGA patient cohorts, PRDM14 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRDM14-associated genes across cancer lineages are eIF4E, GAPDH, and MEK1. Each is linked with PRDM14 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRDM14-to-partner and partner-to-PRDM14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PRDM14-low versus PRDM14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM14→partner) and Y-score (partner→PRDM14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.242	+3.807	.002	<.001	3	3
UCEC	GAPDH →	+0.480	+2.321	.017	.033	3	2
UCEC	MEK1 →	+0.495	+3.906	<.001	<.001	3	2
UCEC	AR →	-0.346	-1.415	.013	.046	3	2
UCEC	ATM →	-0.569	-2.584	<.001	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.598	+2.135	.007	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

eIF4E by PRDM14 expression — UCEC

Explore this box plot interactively →