PRDM14

Across TCGA cell cohorts, PRDM14 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRDM14-associated genes across cancer lineages are CPXCR1, CCER1, and IDI2. Each is linked with PRDM14 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRDM14-to-partner and partner-to-PRDM14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CPXCR1 grouped by PRDM14-low versus PRDM14-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM14→partner) and Y-score (partner→PRDM14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CPXCR1 →	+0.169	+3.707	<.001	.009	3	1
SKIN	CCER1 →	+0.038	+4.437	<.001	.004	3	1
OVARY	IDI2 →	+0.031	+4.444	<.001	.001	3	1
OVARY	LCN9 →	+0.020	+4.222	<.001	.006	3	1
OVARY	ASB17 →	+0.014	+4.222	<.001	.006	3	1
OVARY	CCDC182 →	+0.103	+3.700	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

CPXCR1 by PRDM14 expression — SKIN

Explore this box plot interactively →