PRDM13

Across TCGA patient cohorts, PRDM13 mutation is significantly associated with the RNA expression of many other genes, with 5,341 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRDM13-associated genes across cancer lineages are CDKN3, PSMD9, and OTX1. Each is linked with PRDM13 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRDM13-to-partner and partner-to-PRDM13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDKN3 grouped by PRDM13-low versus PRDM13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM13→partner) and Y-score (partner→PRDM13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDKN3 →	+0.881	+3.534	<.001	<.001	3	3
UCEC	PSMD9 →	+0.463	+2.392	<.001	<.001	3	3
UCEC	OTX1 →	+0.610	+2.534	.004	<.001	3	3
UCEC	DAD1 →	+0.434	+2.917	<.001	<.001	3	3
UCEC	POLA2 →	+0.557	+2.392	<.001	<.001	3	3
UCEC	CDCA5 →	+0.996	+2.885	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,341 associations by consensus.

CDKN3 by PRDM13 expression — UCEC

Explore this box plot interactively →