PRDM13

Across TCGA pan-cancer cohorts, PRDM13 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PRDM13’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PRDM13 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PRDM13 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.

HNSC, COAD, and LUSC are the cancer types where PRDM13 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRDM13 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.667	<.001	10	view →
COAD	All	All	+0.219	.002	7	view →
LUSC	All	II,III,IV	+0.785	<.001	6	view →
UCEC	All	III,IV	+0.091	.024	6	view →
LUAD	All	All	+0.279	<.001	4	view →
BRCA	Female	All	+0.104	.024	4	view →
KIRP	Male	II,III,IV	+0.137	.033	3	view →
PRAD	All	All	+0.025	.045	2	view →
KIRC	Male	III,IV	−0.004	.005	2	view →
THCA	Female	All	+0.006	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PRDM13–HNSC

Open the HNSC breakdown →