PRDM13

Across TCGA patient cohorts, PRDM13 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRDM13-associated genes across cancer lineages are p38-MAPK_pT180_Y182, PCNA, and ATM. Each is linked with PRDM13 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRDM13-to-partner and partner-to-PRDM13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by PRDM13-low versus PRDM13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM13→partner) and Y-score (partner→PRDM13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.473	-1.986	.007	.010	3	2
UCEC	PCNA →	+0.251	+2.700	.003	.006	3	2
UCEC	ATM →	-0.627	-3.446	<.001	.005	3	2
COAD	p27_pT198 →	-0.153	-3.144	.047	.019	3	1
COAD	PDK1_pS241 →	-0.171	-3.161	.039	.019	3	1
COAD	Rad50 →	-0.420	-3.144	<.001	.018	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

p38-MAPK_pT180_Y182 by PRDM13 expression — UCEC

Explore this box plot interactively →