PRDM13

Across TCGA cell cohorts, PRDM13 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible PRDM13-associated genes across cancer lineages are OR13C2, TFDP3, and UBE2QL1. Each is linked with PRDM13 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRDM13-to-partner and partner-to-PRDM13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13C2 grouped by PRDM13-low versus PRDM13-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM13→partner) and Y-score (partner→PRDM13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR13C2 →	+0.042	+4.643	.009	<.001	3	2
LARGE_INTESTINE	TFDP3 →	+0.020	+3.196	.001	.007	3	1
LARGE_INTESTINE	UBE2QL1 →	+0.285	+3.722	<.001	.007	3	1
LARGE_INTESTINE	NEXMIF →	+0.283	+3.196	<.001	.007	3	1
LUNG_SCLC	FASLG →	+0.139	+4.044	<.001	.009	3	1
LUNG_SCLC	TMEM174 →	+0.087	+4.523	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

OR13C2 by PRDM13 expression — OVARY

Explore this box plot interactively →