PRDM12

Across TCGA patient cohorts, PRDM12 mutation is significantly associated with the RNA expression of many other genes, with 300 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRDM12-associated genes across cancer lineages are RBMY1HP, TRBV7-9, and IGLV2-8. Each is linked with PRDM12 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRDM12-to-partner and partner-to-PRDM12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBMY1HP grouped by PRDM12-low versus PRDM12-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM12→partner) and Y-score (partner→PRDM12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RBMY1HP →	+0.024	+7.954	<.001	.008	3	1
UCEC	TRBV7-9 →	+0.852	+3.711	.004	<.001	3	1
UCEC	IGLV2-8 →	+2.421	+3.330	<.001	.005	3	1
UCEC	IGHV3-41 →	+0.954	+3.803	.001	<.001	3	1
UCEC	IGKV1D-12 →	+1.133	+3.332	.001	<.001	3	1
SKCM	OR7A15P →	+0.047	+5.097	.006	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 300 associations by consensus.

RBMY1HP by PRDM12 expression — HNSC

Explore this box plot interactively →