PRDM12

Across TCGA pan-cancer cohorts, PRDM12 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated PRDM12 data layer compared with 8 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher PRDM12 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRDM12 expression acts as an unfavorable survival marker, although some lineages such as READ and STAD show a favorable association.

UVM, KIRC, and HNSC are the cancer types where PRDM12 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.380	0.763	<.001	131	view →
KIRC	OS	Quartile	All	0.495	0.736	<.001	110	view →
HNSC	DFS	Median	II,III,IV	0.247	0.456	.006	47	view →
ACC	DFS	Tertile	All	0.447	0.780	<.001	42	view →
UCS	OS	Median	All	0.398	0.722	.003	34	view →
THCA	DFS	Quartile	IV	0.359	1.000	<.001	32	view →
LIHC	OS	Quartile	All	0.435	0.661	.002	30	view →
UCEC	OS	Quartile	All	0.885	0.934	.001	24	view →
BRCA	DFS	Median	All	0.488	0.549	.020	20	view →
READ	DFS	Median	III,IV	0.557	0.206	.007	19	view →
DLBC	DFS	Median	IV	0.128	1.000	.017	16	view →
KIRP	DFS	Median	All	0.854	0.972	<.001	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

PRDM12–UVM (DFS)

Open the UVM breakdown →