PRDM12

Across TCGA patient cohorts, PRDM12 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRDM12-associated genes across cancer lineages are TIGAR, Bim, and 4E-BP1_pT70. Each is linked with PRDM12 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRDM12-to-partner and partner-to-PRDM12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by PRDM12-low versus PRDM12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM12→partner) and Y-score (partner→PRDM12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.226	+2.486	.002	.011	3	1
UCEC	Bim →	-0.251	-2.459	.048	.020	3	1
UCEC	4E-BP1_pT70 →	+0.136	+2.459	.014	.020	3	1
UCEC	Src →	+0.264	+3.584	.007	.002	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TIGAR by PRDM12 expression — UCEC

Explore this box plot interactively →