PRDM12

Across TCGA cell cohorts, PRDM12 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PRDM12-associated genes across cancer lineages are FGF23, URAD, and PRAMEF6. Each is linked with PRDM12 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRDM12-to-partner and partner-to-PRDM12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FGF23 grouped by PRDM12-low versus PRDM12-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM12→partner) and Y-score (partner→PRDM12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FGF23 →	+0.153	+4.371	<.001	.005	3	1
LUNG_NSCLC_LUAD	URAD →	+0.054	+4.371	<.001	.005	3	1
LUNG_NSCLC_LUAD	PRAMEF6 →	+0.051	+4.947	<.001	.001	3	1
BLOOD_Leukemia	OR52E4 →	+0.029	+5.201	<.001	.006	3	1
BLOOD_Leukemia	AADACL3 →	+0.012	+4.922	<.001	.009	3	1
BLOOD_Leukemia	IQCM →	+0.045	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

FGF23 by PRDM12 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →