PRDM11

Across TCGA patient cohorts, PRDM11 mutation is significantly associated with the RNA expression of many other genes, with 3,412 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRDM11-associated genes across cancer lineages are RNA5SP35, MIR6781, and RNA5SP143. Each is linked with PRDM11 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRDM11-to-partner and partner-to-PRDM11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP35 grouped by PRDM11-low versus PRDM11-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM11→partner) and Y-score (partner→PRDM11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNA5SP35 →	+0.235	+3.681	.006	.005	3	3
UCEC	MIR6781 →	+0.443	+1.459	<.001	.007	3	3
SKCM	RNA5SP143 →	+0.103	+3.462	<.001	.003	3	3
HNSC	MIR6821 →	+0.656	+3.887	<.001	.004	3	3
LGG	FABP5P12 →	+0.159	+5.266	<.001	.006	3	3
HNSC	RNU6-1107P →	+0.186	+4.339	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,412 associations by consensus.

RNA5SP35 by PRDM11 expression — HNSC

Explore this box plot interactively →