PRDM11

Across TCGA pan-cancer cohorts, PRDM11 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PRDM11 data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher PRDM11 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PRDM11 expression acts as an unfavorable survival marker, although some lineages such as BRCA and UCS show a favorable association.

BRCA, UCS, and LGG are the cancer types where PRDM11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Tertile	III,IV	0.619	0.434	<.001	55	view →
UCS	OS	Quartile	II,III,IV	0.765	0.204	.001	46	view →
LGG	OS	Tertile	All	0.519	0.375	<.001	43	view →
ACC	DFS	Median	II,III,IV	0.241	0.609	<.001	43	view →
PAAD	OS	Median	All	0.464	0.292	.003	32	view →
KIRC	OS	Tertile	All	0.736	0.564	.001	31	view →
HNSC	OS	Quartile	IV	0.520	0.343	.007	25	view →
UVM	DFS	Median	All	0.908	0.573	.002	24	view →
GBM	OS	Median	All	0.534	0.292	.006	15	view →
DLBC	DFS	Tertile	All	0.664	1.000	.006	15	view →
READ	OS	Median	All	0.938	0.437	.015	12	view →
CHOL	DFS	Tertile	All	0.535	0.119	.010	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PRDM11–BRCA (OS)

Open the BRCA breakdown →