PRDM11

Across TCGA cell cohorts, PRDM11 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRDM11-associated genes across cancer lineages are GHRHR, HHLA1, and SELENOV. Each is linked with PRDM11 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRDM11-to-partner and partner-to-PRDM11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHRHR grouped by PRDM11-low versus PRDM11-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM11→partner) and Y-score (partner→PRDM11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GHRHR →	+0.377	+3.705	<.001	.007	3	1
BLOOD_Leukemia	HHLA1 →	+0.009	+3.551	<.001	.009	3	1
BLOOD_Leukemia	SELENOV →	+0.087	+4.339	<.001	.002	3	1
BLOOD_Leukemia	SLC6A17 →	+0.213	+4.037	<.001	.004	3	1
BLOOD_Leukemia	TSSK1B →	+0.011	+3.874	<.001	.005	3	1
LARGE_INTESTINE	KCNK17 →	+0.072	+3.333	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

GHRHR by PRDM11 expression — BLOOD_Leukemia

Explore this box plot interactively →