PRCC

Across TCGA patient cohorts, PRCC mutation is significantly associated with the RNA expression of many other genes, with 286 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PRCC-associated genes across cancer lineages are YPEL5P1, PPP1R26P3, and TUBAP1. Each is linked with PRCC in more than 1 cancer types. Because this analysis shows association rather than direction, both PRCC-to-partner and partner-to-PRCC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YPEL5P1 grouped by PRCC-low versus PRCC-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRCC→partner) and Y-score (partner→PRCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	YPEL5P1 →	+0.140	+4.893	<.001	.005	3	2
BLCA	PPP1R26P3 →	+0.008	+4.122	<.001	.008	3	2
UCEC	TUBAP1 →	+0.078	+2.185	.006	.006	3	2
UCEC	RALBP1P2 →	+0.147	+2.372	.003	.003	3	2
UCEC	ACSL1 →	+0.866	+3.201	.001	.009	3	2
BLCA	ARL2BPP4 →	+0.061	+3.495	.006	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 286 associations by consensus.

YPEL5P1 by PRCC expression — COAD

Explore this box plot interactively →