Across TCGA cell cohorts, PRC1 mutation is significantly associated with the mutation status of many other genes, with 2,489 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRC1-associated genes across cancer lineages are MAP7D1, KIAA0319L, and TADA3. Each is linked with PRC1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PRC1-to-partner and partner-to-PRC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRC1→partner) and Y-score (partner→PRC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAP7D1 →	+2.422	+4.050	.004	.004	1	4
SKIN	KIAA0319L →	+3.357	+3.532	.005	.005	1	3
LARGE_INTESTINE	TADA3 →	+4.159	+5.215	<.001	<.001	1	3
SKIN	AP2A2 →	+4.357	+4.053	.001	.001	1	3
BLOOD_Leukemia	EPN2 →	+4.736	+5.560	.003	.003	1	3
BLOOD_Leukemia	AACS →	+4.321	+5.285	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,489 associations by consensus.

Exploration

PRC1 survival (RNA) · tumor vs normal (RNA) · all PRC1 data types