PRAP1

Across TCGA cell cohorts, PRAP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,567 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRAP1-associated GO terms across cancer lineages are Deactivation of mitotic spindle assembly checkpoint, Regulation of myoblast fusion, and Positive regulation of double-strand break repair. Each is linked with PRAP1 in more than 8 cancer types. Because this analysis shows association rather than direction, both PRAP1-to-partner and partner-to-PRAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Deactivation of mitotic spindle assembly checkpoint grouped by PRAP1-low versus PRAP1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAP1→partner) and Y-score (partner→PRAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Deactivation of mitotic spindle assembly checkpoint →	-0.184	-0.756	.001	<.001	3	9
BONE	Regulation of myoblast fusion →	+0.094	+0.599	<.001	.002	2	8
BONE	Positive regulation of double-strand break repair →	+0.075	+0.476	<.001	.002	3	7
BONE	Regulation of syncytium formation by plasma membrane fusion →	+0.087	+0.547	<.001	.006	2	8
BONE	Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway →	+0.154	+0.566	<.001	<.001	3	7
BONE	Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway →	+0.111	+0.540	.002	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,567 associations by consensus.

Deactivation of mitotic spindle assembly checkpoint by PRAP1 expression — BONE

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