PRAP1

Across TCGA pan-cancer cohorts, PRAP1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PRAP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PRAP1 RNA is repressed in tumor relative to normal tissue. In most cancer types PRAP1 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, KIRP, and HNSC are the cancer types where PRAP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRAP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−5.056	<.001	9	view →
KIRP	All	III,IV	−4.068	<.001	8	view →
HNSC	All	All	+0.556	<.001	6	view →
LUSC	All	All	+0.632	<.001	5	view →
BRCA	All	All	−0.204	<.001	4	view →
CHOL	All	All	−4.885	<.001	3	view →
STAD	All	II,III,IV	+2.126	.044	2	view →
COAD	Female	II,III,IV	−1.577	.008	2	view →
THCA	Male	III,IV	−0.082	.041	2	view →
LIHC	Male	All	+0.771	.044	1	view →
LUAD	All	All	+0.301	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PRAP1–KICH

Open the KICH breakdown →