PRAMEF8

Across TCGA patient cohorts, PRAMEF8 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,706 significant associations in total. STAD shows the largest number of these associations.

The most reproducible PRAMEF8-associated GO terms across cancer lineages are Protein insertion into membrane, 5-phosphoribose 1-diphosphate metabolic process, and Regulation of generation of precursor metabolites and energy. Each is linked with PRAMEF8 in more than 4 cancer types. Because this analysis shows association rather than direction, both PRAMEF8-to-partner and partner-to-PRAMEF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein insertion into membrane grouped by PRAMEF8-low versus PRAMEF8-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF8→partner) and Y-score (partner→PRAMEF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Protein insertion into membrane →	+0.104	+0.023	<.001	.002	3	5
THYM	5-phosphoribose 1-diphosphate metabolic process →	+0.078	+0.111	<.001	.003	3	5
STAD	Regulation of generation of precursor metabolites and energy →	+0.092	+0.015	<.001	.004	3	5
STAD	Peroxisome organization →	+0.089	+0.023	<.001	.003	3	5
STAD	Regulation of transcription elongation by RNA polymerase II →	+0.108	+0.029	<.001	.004	2	5
STAD	Negative regulation of cyclin-dependent protein serine/threonine kinase activity →	+0.073	+0.030	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,706 associations by consensus.

Protein insertion into membrane by PRAMEF8 expression — STAD

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