PRAMEF8

Across TCGA patient cohorts, PRAMEF8 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRAMEF8-associated genes across cancer lineages are Ku80, CD20, and TIGAR. Each is linked with PRAMEF8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRAMEF8-to-partner and partner-to-PRAMEF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by PRAMEF8-low versus PRAMEF8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF8→partner) and Y-score (partner→PRAMEF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.424	+2.820	.003	.036	3	1
UCEC	CD20 →	+0.190	+2.827	.018	.035	3	1
UCEC	TIGAR →	+0.203	+2.833	.029	.035	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Ku80 by PRAMEF8 expression — UCEC

Explore this box plot interactively →