PRAMEF8

Across TCGA cell cohorts, PRAMEF8 RNA expression is significantly associated with the mutation status of many other genes, with 62 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PRAMEF8-associated genes across cancer lineages are MKNK2, CACNA2D1, and KDM5C. Each is linked with PRAMEF8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRAMEF8-to-partner and partner-to-PRAMEF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MKNK2 grouped by PRAMEF8-low versus PRAMEF8-high in BLOOD_Lymphoma.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF8→partner) and Y-score (partner→PRAMEF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MKNK2 →	+3.584	+0.022	.004	.001	3	2
CNS	CACNA2D1 →	+3.459	+0.215	.006	<.001	3	2
LUNG_NSCLC_LUAD	KDM5C →	+4.544	+0.018	.003	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	ASTN1 →	+3.510	+0.149	.007	<.001	3	2
LUNG_NSCLC_LUSC	LTBP2 →	+4.643	+0.046	.008	<.001	3	1
LUNG_NSCLC_LUSC	CA1 →	+4.643	+0.046	.008	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

MKNK2 by PRAMEF8 expression — BLOOD_Lymphoma

Explore this box plot interactively →