PRAMEF2

Across TCGA patient cohorts, PRAMEF2 protein abundance is significantly associated with the RNA expression of many other genes, with 7,808 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PRAMEF2-associated genes across cancer lineages are RAB24, RBM34, and KLHL23. Each is linked with PRAMEF2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PRAMEF2-to-partner and partner-to-PRAMEF2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRAMEF2 versus RAB24 in GBM, with a Pearson correlation of -0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF2→partner) and Y-score (partner→PRAMEF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RAB24 →	-0.540	-0.834	<.001	<.001	3	3
UCEC	RBM34 →	-1.224	-0.879	<.001	.007	3	3
LSCC	KLHL23 →	-1.036	-0.552	.001	.006	3	3
GBM	HSPBP1 →	-0.486	-0.635	.001	.003	3	3
GBM	KLC2 →	-0.558	-0.590	<.001	.004	2	4
COAD	CIAO3 →	-0.318	-0.556	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,808 associations by consensus.

PRAMEF2 vs RAB24 — GBM

Explore this scatter interactively →