PRAMEF2

Across TCGA cell cohorts, PRAMEF2 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PRAMEF2-associated genes across cancer lineages are RGR, CLRN1, and GABRA6. Each is linked with PRAMEF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRAMEF2-to-partner and partner-to-PRAMEF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RGR grouped by PRAMEF2-low versus PRAMEF2-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF2→partner) and Y-score (partner→PRAMEF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RGR →	+0.006	+5.087	<.001	.004	3	2
URINARY_TRACT	CLRN1 →	+0.033	+5.087	<.001	.004	3	1
LUNG_NSCLC_LUAD	GABRA6 →	+0.096	+5.189	<.001	<.001	3	1
LUNG_NSCLC_LUAD	TAAR8 →	+0.017	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	SLC22A8 →	+0.027	+4.212	<.001	.007	3	1
LUNG_NSCLC_LUAD	UMOD →	+0.005	+5.266	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

RGR by PRAMEF2 expression — URINARY_TRACT

Explore this box plot interactively →