PRAMEF11

Across TCGA patient cohorts, PRAMEF11 mutation is significantly associated with the RNA expression of many other genes, with 3,491 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRAMEF11-associated genes across cancer lineages are FANCG, PHC2-AS1, and EEF1E1-BLOC1S5. Each is linked with PRAMEF11 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRAMEF11-to-partner and partner-to-PRAMEF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FANCG grouped by PRAMEF11-low versus PRAMEF11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF11→partner) and Y-score (partner→PRAMEF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FANCG →	+0.626	+2.815	<.001	.001	3	3
UCEC	PHC2-AS1 →	+0.368	+3.733	.001	.001	3	3
CESC	EEF1E1-BLOC1S5 →	+0.042	+4.969	<.001	.004	3	3
LUAD	MAGEA2B →	+0.106	+2.948	.002	.005	3	3
LUAD	LINC02163 →	+1.482	+3.430	<.001	.009	3	3
SKCM	KIFC1 →	+0.451	+1.864	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,491 associations by consensus.

FANCG by PRAMEF11 expression — UCEC

Explore this box plot interactively →