PRAMEF11

Across TCGA patient cohorts, PRAMEF11 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRAMEF11-associated genes across cancer lineages are C-Raf, HER2, and Stathmin. Each is linked with PRAMEF11 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRAMEF11-to-partner and partner-to-PRAMEF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by PRAMEF11-low versus PRAMEF11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF11→partner) and Y-score (partner→PRAMEF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.138	+1.700	.022	.044	3	3
SKCM	HER2 →	+0.214	+1.700	.023	.038	3	2
SKCM	Stathmin →	+0.141	+1.321	.018	.028	3	2
UCEC	eEF2 →	+0.494	+2.321	.001	.034	3	2
UCEC	MEK1 →	+0.421	+3.459	.006	.005	3	2
SKCM	p27_pT157 →	+0.115	+1.321	.001	.028	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

C-Raf by PRAMEF11 expression — UCEC

Explore this box plot interactively →