PRAMEF11

Across TCGA cell cohorts, PRAMEF11 RNA expression is significantly associated with the mutation status of many other genes, with 179 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PRAMEF11-associated genes across cancer lineages are ARPP21, CACNA2D1, and REV3L. Each is linked with PRAMEF11 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRAMEF11-to-partner and partner-to-PRAMEF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARPP21 grouped by PRAMEF11-low versus PRAMEF11-high in BLOOD_Lymphoma.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF11→partner) and Y-score (partner→PRAMEF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ARPP21 →	+4.247	+0.003	.004	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	CACNA2D1 →	+4.736	+0.192	.009	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	REV3L →	+4.736	+0.192	.009	<.001	3	2
LUNG_NSCLC_LUAD	CHD5 →	+2.440	+0.001	.008	<.001	3	2
LUNG_NSCLC_LUAD	ADGRB3 →	+2.440	+0.001	.008	<.001	3	2
BLOOD_Myeloma	APBA1 →	+3.584	+0.599	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 179 associations by consensus.

ARPP21 by PRAMEF11 expression — BLOOD_Lymphoma

Explore this box plot interactively →