PRAMEF11

Across TCGA cell cohorts, PRAMEF11 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRAMEF11-associated genes across cancer lineages are KRTAP9-3, OR10C1, and OCM2. Each is linked with PRAMEF11 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRAMEF11-to-partner and partner-to-PRAMEF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP9-3 grouped by PRAMEF11-low versus PRAMEF11-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF11→partner) and Y-score (partner→PRAMEF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KRTAP9-3 →	+0.042	+4.643	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR10C1 →	+0.050	+5.266	<.001	.001	3	1
LARGE_INTESTINE	OCM2 →	+0.047	+3.700	<.001	.009	3	1
LARGE_INTESTINE	GPR6 →	+0.005	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	OR4F4 →	+0.015	+3.103	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

KRTAP9-3 by PRAMEF11 expression — LUNG_SCLC

Explore this box plot interactively →