Across TCGA patient cohorts, PRAME mutation is significantly associated with the RNA expression of many other genes, with 2,790 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRAME-associated genes across cancer lineages are HMGN2P22, GPR180, and SPINDOC. Each is linked with PRAME in more than 2 cancer types. Because this analysis shows association rather than direction, both PRAME-to-partner and partner-to-PRAME results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAME→partner) and Y-score (partner→PRAME) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	HMGN2P22 →	+0.289	+4.868	<.001	.002	3	3
UCEC	GPR180 →	+0.507	+2.265	<.001	.005	3	3
UCEC	SPINDOC →	+0.377	+2.238	.008	.006	3	3
UCEC	MTIF2 →	+0.359	+2.455	.006	.001	3	3
COAD	OR51B2 →	+0.078	+5.409	<.001	.001	3	3
SKCM	PPP4R1 →	+0.465	+2.341	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,790 associations by consensus.

Exploration

PRAME survival (RNA) · tumor vs normal (RNA) · all PRAME data types