PRAM1

Across TCGA patient cohorts, PRAM1 mutation is significantly associated with the RNA expression of many other genes, with 4,525 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRAM1-associated genes across cancer lineages are JOSD1, MCM5, and PRMT5. Each is linked with PRAM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRAM1-to-partner and partner-to-PRAM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JOSD1 grouped by PRAM1-low versus PRAM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAM1→partner) and Y-score (partner→PRAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JOSD1 →	+0.481	+2.857	<.001	<.001	3	3
UCEC	MCM5 →	+0.677	+2.496	<.001	<.001	3	3
UCEC	PRMT5 →	+0.546	+1.643	.004	.003	3	3
UCEC	CDKN3 →	+0.799	+1.903	<.001	<.001	3	3
UCEC	VRK1 →	+0.465	+1.665	.004	.002	3	3
UCEC	NEIL3 →	+0.559	+1.893	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,525 associations by consensus.

JOSD1 by PRAM1 expression — UCEC

Explore this box plot interactively →