PRAM1

Across TCGA pan-cancer cohorts, PRAM1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PRAM1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PRAM1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PRAM1 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

KIRC, KIRP, and THCA are the cancer types where PRAM1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRAM1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	+1.441	<.001	12	view →
KIRP	Male	All	+1.569	<.001	11	view →
THCA	All	IV	+1.102	<.001	10	view →
LUSC	Male	All	−2.501	<.001	9	view →
LUAD	Male	All	−2.099	<.001	9	view →
STAD	Male	II,III,IV	+0.790	<.001	7	view →
LIHC	Male	III,IV	−0.676	<.001	7	view →
COAD	All	II,III,IV	+0.323	.008	7	view →
UCEC	All	All	−0.629	<.001	6	view →
PAAD	All	All	−1.477	.031	2	view →
ESCA	All	II,III,IV	+1.070	.037	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PRAM1–KIRC

Open the KIRC breakdown →