PRAM1

Across TCGA patient cohorts, PRAM1 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRAM1-associated genes across cancer lineages are PCNA, Cyclin-B1, and Cyclin-E2. Each is linked with PRAM1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PRAM1-to-partner and partner-to-PRAM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PRAM1-low versus PRAM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAM1→partner) and Y-score (partner→PRAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.272	+3.807	<.001	<.001	3	3
UCEC	Cyclin-B1 →	+0.846	+2.523	<.001	<.001	2	4
UCEC	Cyclin-E2 →	+0.129	+1.247	.024	.045	3	3
UCEC	STAT3_pY705 →	-0.366	-2.415	<.001	.002	3	2
UCEC	eEF2 →	+0.338	+1.514	.005	.015	3	2
UCEC	EGFR_pY1068 →	-0.292	-1.807	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

PCNA by PRAM1 expression — UCEC

Explore this box plot interactively →