PRAM1

Across TCGA cell cohorts, PRAM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,831 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRAM1-associated GO terms across cancer lineages are Myosin filament organization, Myosin filament assembly, and Positive regulation of intracellular steroid hormone receptor signaling pathway. Each is linked with PRAM1 in more than 11 cancer types. Because this analysis shows association rather than direction, both PRAM1-to-partner and partner-to-PRAM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Myosin filament organization grouped by PRAM1-low versus PRAM1-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAM1→partner) and Y-score (partner→PRAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Myosin filament organization →	-0.376	-0.245	.002	<.001	3	12
CNS	Myosin filament assembly →	-0.376	-0.245	.002	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.173	+0.356	<.001	.001	3	12
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.135	+0.322	.001	.002	3	10
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.134	+0.309	.001	.003	3	10
OESOPHAGUS	mRNA splice site recognition →	+0.156	+0.427	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,831 associations by consensus.

Myosin filament organization by PRAM1 expression — CNS

Explore this box plot interactively →