PRAM1

Across TCGA cell cohorts, PRAM1 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRAM1-associated genes across cancer lineages are C8A, KRTAP4-11, and TMEM210. Each is linked with PRAM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRAM1-to-partner and partner-to-PRAM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C8A grouped by PRAM1-low versus PRAM1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAM1→partner) and Y-score (partner→PRAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C8A →	+0.020	+3.514	<.001	.001	3	2
CNS	KRTAP4-11 →	+0.615	+4.981	<.001	.008	3	1
LARGE_INTESTINE	TMEM210 →	+0.085	+3.333	.006	.009	3	1
SKIN	CLEC4E →	+0.104	+3.347	<.001	.005	3	1
SKIN	GPR152 →	+0.039	+3.347	.001	.005	3	1
SKIN	H4C13 →	+0.338	+3.196	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

C8A by PRAM1 expression — LARGE_INTESTINE

Explore this box plot interactively →