PRAC1

Across TCGA patient cohorts, PRAC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,482 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible PRAC1-associated GO terms across cancer lineages are Oxidative phosphorylation, Embryonic skeletal system development, and Positive regulation of nuclear cell cycle DNA replication. Each is linked with PRAC1 in more than 9 cancer types. Because this analysis shows association rather than direction, both PRAC1-to-partner and partner-to-PRAC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Oxidative phosphorylation grouped by PRAC1-low versus PRAC1-high in HNSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAC1→partner) and Y-score (partner→PRAC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	Oxidative phosphorylation →	+0.035	+0.179	<.001	<.001	3	9
SARC	Embryonic skeletal system development →	+0.033	+0.533	<.001	<.001	3	9
UCEC	Positive regulation of nuclear cell cycle DNA replication →	+0.031	+0.267	<.001	<.001	3	8
TGCT	Regulation of cellular senescence →	+0.053	+2.014	<.001	<.001	3	8
ESCA	Establishment of mitotic spindle localization →	+0.062	+0.305	<.001	.009	1	10
TGCT	Spindle localization →	+0.035	+1.236	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,482 associations by consensus.

Oxidative phosphorylation by PRAC1 expression — HNSC

Explore this box plot interactively →