PRAC1

Across TCGA pan-cancer cohorts, PRAC1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PRAC1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PRAC1 RNA is repressed in tumor relative to normal tissue. In most cancer types PRAC1 is over-expressed in tumor, although a few such as BLCA show the opposite, repressed pattern.

BLCA, PRAD, and LUSC are the cancer types where PRAC1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRAC1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	All	−3.715	<.001	11	view →
PRAD	All	All	+1.683	<.001	2	view →
LUSC	All	All	+0.238	.007	2	view →
KIRC	Female	All	+0.040	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

PRAC1–BLCA

Open the BLCA breakdown →