PPT1

Across TCGA pan-cancer cohorts, PPT1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PPT1 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PPT1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPT1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

COAD, UCEC, and HNSC are the cancer types where PPT1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.806	1.000	.011	90	view →
UCEC	DFS	Quartile	II,III,IV	0.283	0.889	.009	28	view →
HNSC	DFS	Tertile	All	0.606	0.825	.025	9	view →
CCRCC	OS	Quartile	II,III,IV	1.000	0.740	.029	7	view →
LSCC	OS	Median	III,IV	0.996	0.725	.031	4	view →
LUAD	DFS	Quartile	All	1.000	0.625	.026	2	view →
PDAC	DFS	Quartile	III,IV	0.171	0.521	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PPT1–COAD (DFS)

Open the COAD breakdown →