PPT1

Across TCGA patient cohorts, PPT1 mutation is significantly associated with the RNA expression of many other genes, with 243 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPT1-associated genes across cancer lineages are RNU4-56P, RNA5SP518, and WHAMM. Each is linked with PPT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPT1-to-partner and partner-to-PPT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-56P grouped by PPT1-low versus PPT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPT1→partner) and Y-score (partner→PPT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU4-56P →	+0.226	+3.845	.001	.001	3	2
LUSC	RNA5SP518 →	+0.358	+7.924	<.001	.008	3	2
UCEC	WHAMM →	+0.478	+3.234	.001	.009	3	1
UCEC	ZC3H18 →	+0.567	+3.375	<.001	.004	3	1
UCEC	SLC45A3 →	-0.677	-3.563	.003	.003	3	1
UCEC	NEXN →	+0.945	+3.329	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 243 associations by consensus.

RNU4-56P by PPT1 expression — UCEC

Explore this box plot interactively →