PPP5C

Across TCGA pan-cancer cohorts, PPP5C mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated PPP5C data layer compared with 28 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PPP5C mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PPP5C expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and COAD are the cancer types where PPP5C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.667	0.420	<.001	61	view →
CCRCC	DFS	Tertile	IV	1.000	0.108	.024	21	view →
COAD	DFS	Median	IV	0.493	0.944	.031	18	view →
LSCC	DFS	Median	III,IV	0.990	0.575	.006	18	view →
GBM	DFS	Tertile	All	0.211	0.523	.008	7	view →
UCEC	OS	Quartile	All	0.834	1.000	.022	4	view →
LUAD	DFS	Quartile	III,IV	0.759	0.371	.048	3	view →
HNSC	DFS	Median	IV	1.000	0.924	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

PPP5C–PDAC (OS)

Open the PDAC breakdown →