PPP5C

Across TCGA pan-cancer cohorts, PPP5C mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PPP5C’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PPP5C mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PPP5C is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, PDAC, and LUAD are the cancer types where PPP5C tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP5C mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−0.263	<.001	9	view →
PDAC	Male	II,III,IV	+0.424	<.001	8	view →
LUAD	Female	II,III,IV	−0.212	<.001	8	view →
CCRCC	All	IV	−0.165	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

PPP5C–COAD

Open the COAD breakdown →