PPP4R4

Across TCGA pan-cancer cohorts, PPP4R4 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated PPP4R4 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PPP4R4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PPP4R4 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LSCC and GBM are the cancer types where PPP4R4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	All	1.000	0.918	.016	2	view →
GBM	DFS	Median	All	0.453	0.286	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

PPP4R4–LSCC (OS)

Open the LSCC breakdown →