PPP4R4

Across TCGA pan-cancer cohorts, PPP4R4 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of PPP4R4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PPP4R4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPP4R4 is over-expressed in tumor, although a few such as KIRC and LUAD show the opposite, repressed pattern.

HNSC, KIRC, and LUAD are the cancer types where PPP4R4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP4R4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+2.244	<.001	12	view →
KIRC	Female	All	−0.564	<.001	11	view →
LUAD	Male	II,III,IV	−1.676	<.001	9	view →
CHOL	All	All	−0.962	<.001	5	view →
BLCA	All	All	+0.740	.014	5	view →
LUSC	All	II,III,IV	−0.736	.012	5	view →
THCA	Male	All	−0.250	<.001	5	view →
UCEC	All	All	−1.262	<.001	4	view →
LIHC	Male	All	+0.389	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

PPP4R4–HNSC

Open the HNSC breakdown →