PPP4R4

Across TCGA patient cohorts, PPP4R4 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP4R4-associated genes across cancer lineages are ASNS, ATM, and Caspase-7-cleavedD198. Each is linked with PPP4R4 in more than 2 cancer types. Because this analysis shows association rather than direction, both PPP4R4-to-partner and partner-to-PPP4R4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by PPP4R4-low versus PPP4R4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP4R4→partner) and Y-score (partner→PPP4R4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ASNS →	+0.352	+2.321	.023	.033	3	3
UCEC	ATM →	-0.497	-2.058	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.706	+3.107	<.001	<.001	3	3
SKCM	Smad4 →	+0.084	+1.734	.037	.021	3	2
UCEC	N-Cadherin →	+0.133	+1.700	.049	.040	3	2
UCEC	PDCD4 →	-0.459	-1.289	.002	.023	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

ASNS by PPP4R4 expression — SKCM

Explore this box plot interactively →