PPP4R4

Across TCGA cell cohorts, PPP4R4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,328 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PPP4R4-associated GO terms across cancer lineages are Regulation of post-translational protein modification, Regulation of DNA biosynthetic process, and Cytoplasmic translation. Each is linked with PPP4R4 in more than 9 cancer types. Because this analysis shows association rather than direction, both PPP4R4-to-partner and partner-to-PPP4R4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of post-translational protein modification grouped by PPP4R4-low versus PPP4R4-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP4R4→partner) and Y-score (partner→PPP4R4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of post-translational protein modification →	+0.074	+1.346	<.001	.003	3	10
URINARY_TRACT	Regulation of DNA biosynthetic process →	+0.073	+1.415	.002	.001	3	9
PANCREAS	Cytoplasmic translation →	+0.088	+1.057	<.001	<.001	3	9
PANCREAS	Nuclear export →	+0.058	+0.796	<.001	<.001	3	9
PANCREAS	Regulation of organelle assembly →	+0.050	+1.116	<.001	<.001	3	8
OVARY	Microtubule cytoskeleton organization involved in mitosis →	+0.082	+1.011	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,328 associations by consensus.

Regulation of post-translational protein modification by PPP4R4 expression — STOMACH

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